Ultimate Dog

By Sara Seitz - Reading Time: 16 minutes

5 Apoquel Alternatives That Are Better for Your Dog

I remember when Apoquel first hit the market. For dogs with chronic allergy dermatitis and uncontrollable itching, it was a godsend. And for one of my training clients, in particular, it was life-changing.

He was a brindle boxer with a spastic personality and a bag of health problems. Among his many ailments were chronic pruritus, atopic dermatitis, and frequent hot spots. He was a mess.

Apoquel changed everything. Within just a couple weeks, his skin looked less inflamed and the constant itching was noticeably reduced. But that wasn’t the only change I noticed. He also bloated up, lost his energy, and became a mere shadow of the dog he once was.

Unfortunately, his story is not unique.

So many dogs and their owners find themselves in a catch twenty-two with Apoquel. The medication works brilliantly to stop itching, but always at a cost. Whether it’s to your dog’s health or your wallet.

It’s these reasons that drive many desperate owners to consider alternatives to Apoquel. Unfortunately, it isn’t as easy as picking up a cheaper pill with fewer side effects. But the good news is, there are safe and effective alternatives out there.

In this article, we’ll look at the potential problems associated with Apoquel and discuss the effectiveness of alternate routes to cure your dog’s dermatitis, including natural remedies, possible Apoquel substitutes, and addressing the root cause of the issue.

Side Effects and Other Pitfalls of Apoquel

Apoquel isn’t a drug meant for acute dermatitis or short term use. It’s a drug vets turn to when the cause of their patient’s itching can’t be easily determined or has persisted through other treatment options. Once a dog is started on Apoquel, they are usually stuck on the drug for life.

Before you make such a monumental decision about your pup’s healthcare, it’s worth looking at the risks associated with this drug.

Known Side Effects

While vomiting and diarrhea are common with many meds, including Apoquel, this drug also comes with its own special list of worrisome side effects.

Apoquel works by disrupting kinase pathways within your dog’s immune system. While this leads to a reduction in skin irritation and itchiness, it also interferes with the immune system’s ability to complete other important tasks as effectively.

Just like immune-suppressing drugs used in humans, Apoquel is linked to an increased rate of infection in dogs. The most common infections are Demodex mange, ear infections, and pneumonia. It is because of the potential for serious infection that this drug cannot be used in dogs under a year of age who naturally have weaker immune systems.

In all dogs, there is also a potential for bone marrow suppression and reduced white blood cell count.

But kinase pathways aren’t just isolated within the immune system. They play a huge role throughout the body. That fact might explain why more surprising side effects like anorexia, lethargy, and increased cholesterol and blood lipase are often seen in dogs on Apoquel.

The Cancer Link

We often think of our immune system as being responsible for fighting invaders from the outside world, but our immune system also plays a key role in fighting cancer within our bodies. And your dog is no different.

By far, the most worrisome side effect of Apoquel is the potential to increase cancer rates.

The third listed side effect on the box explains that Apoquel may “exacerbate neoplastic conditions.” This means that in laboratory tests, this drug was found to make preexisting cancers worse. This shouldn’t come as a huge surprise given the way this drug functions. By disrupting the normal activity of the immune system, Apoquel reduces your dog’s ability to fight cancer cells.

While there is no evidence that Apoquel itself causes cancer cell growth, it’s not much of a leap to say that your dog is more likely to develop cancer on the drug than if they weren’t taking it. In fact, in one long term study, 5% of dogs on Apoquel were diagnosed with some form of cancer within 392 days of starting the drug.

This number is almost equal to the percent of dogs in most studies that experienced vomiting while on the drug, a side effect that is considered common with Apoquel.

Increased cancer rates may be an acceptable risk for a drug to prevent organ rejection, but it is up to you to decide if this risk is worth it to help your dog find relief from chronic itching.

Becoming Dependent

As disturbing as the side effects of Apoquel seem to be, the real threat of this drug in my mind is how addictive it is to your dog’s system.

Apoquel is not a drug meant for acute conditions, but instead for skin issues that have typically plagued a dog for a long time. For that reason, most dogs are prescribed this drug without any expectation that they’ll ever be taken off of it. It makes sense when you consider a dog like my former client, the brindle boxer. Here was a pooch that had been struggling with chronically itchy skin for years. And his owners finally had a treatment that worked, so why would they stop using it?

Unfortunately for them, the usefulness of the drug is actually what forced them to stop using it, at least briefly. Shortly after Apoquel hit the market, the demand for the drug overtook Zoetis’ ability to produce it. Thousands of dogs were forced off the drug cold turkey. I remember how ferociously the irritated, inflamed, and itchy skin returned for that poor boxer. It was as if his condition was worse than it had been before the medication.

It turns out that this wasn’t just a matter of perception, either.

Apoquel isn’t a cure for the underlying cause of atopic or allergic dermatitis. Instead, it is a bandaid that forces your dog’s immune system to compensate for the destruction it causes. And once the bandaid is removed, not only will the itch return, but your dog’s entire immune system can fall into chaos as the newly unimpeded kinase pathways attempt to reconcile with the restructured system.

If your dog’s dermatitis seems too unbearable now to attempt another form of treatment, take a moment to consider that it will likely be far worse after a few months or years on Apoquel.

It’s Pricey

While the potential for cancer growth and dependence are risks all owners should consider, it’s the price of Apoquel that often leads owners to hunt for an alternative.

Little has changed in the six years since this drug came on the market. It is still a revolutionary and unrivaled treatment for severe itching that you can get only with a prescription from your vet. And the price more than reflects Apoquel’s dominance over the market.

The go-to choice for allergic dermatitis used to be prednisone, a drug that costs on average 800% less than Apoquel. But when comparing the effectiveness of the two treatments, there’s generally no contest.

When owners realize they may be paying this inflated price for the rest of their dog’s life, they often ask: Is there a generic for Apoquel? The short answer is a resounding no. In fact, the patent doesn’t expire in the US until 2026, making it unlikely we’ll see anything to rival this drug in the near future.

Your options for Apoquel substitutes are therefore limited to the old standbys for allergy-induced itchiness.

Atopica was most vet’s go-to choice for atopic dermatitis before Apoquel came along. Unfortunately, the reason it was ditched in favor of the new drug was because it came with its own set of disturbing side effects, most even worse than what we are now seeing with Apoquel. The price also rivals Apoquel’s, making this drug a poor substitute all around.

Prednisone and other steroids are options that have long been used to treat itchy and inflamed skin. Unfortunately, these drugs have less of a desired effect than Apoquel and are not recommended for long term use.

When it comes to Apoquel versus Benadryl, chlorpheniramine and other antihistamines for dermatitis, there really is no contest. Antihistamines are considered to have little to no effect on itching in most dogs and are rarely recommended to treat allergic dermatitis. However, they are significantly safer to use than other drugs and might be worth a try for the desperate owner looking for a short term solution while they employ one of the alternatives listed below.

5 Safer Alternatives to Apoquel

1. Addressing Environmental Allergens

As I mentioned above, dermatitis is never a condition in and of itself, but always the symptom of a larger issue. Figuring out what that issue is and treating it rather than treating just the symptom is much more likely to lead down a path towards a cure for your dog’s itching.

And considering that 70% of canine skin conditions are allergy-related, addressing environmental allergens is a good place to start. Of dogs who do suffer from allergic dermatitis, around 90% of them are reacting to an allergy in the air or from surface contact. The most common allergens are dust mites, protein in flea saliva, and pollen.

If your dog only suffers from itchy skin in the spring and fall, then they probably have seasonal allergies caused by plant pollen. At least with this diagnosis, you have the option to use drug therapy sparingly. But remember, drugs like Apoquel often create dependence and are not easy to take your dog off of.

Instead of turning to drugs, there are other options available that can significantly reduce and even cure your dog’s underlying allergies.

Using high-powered air purifiers indoors, changing HVAC filters frequently, and reducing your dog’s contact with known allergens like grass, can help reduce symptoms significantly. But for dogs with highly sensitive skin, multiple allergies, or severe allergies, this might not be enough.

In this case, you may consider immunotherapy to potentially cure your dog’s allergies altogether.

Immunotherapy works the same way in dogs as it does in people. Tests are done to determine what your dog is allergic to. Then your dog is given a series of shots or oral drops over the course of days to weeks to slowly introduce the offending allergen to their system. Over time, the number of doses is decreased and the amount of allergen per dose is increased.

In about 70% of dogs, the immune system will become accustomed to the allergen and stop reacting to it, leading to a reduction or complete disappearance of dermatitis.

2. Changing Your Dog’s Diet

So what about the 10 to 15% of dogs who suffer from allergic dermatitis but aren’t reacting to environmental allergens? These dogs are most likely allergic to something in their diet.

While true food allergies are relatively rare, food sensitivities and intolerances are far more common and can also lead to red and itchy skin in dogs. If you believe your dog’s dermatitis is caused by something in their food, your best option to find relief is an elimination diet.

In an elimination diet, you will remove all possible allergens from your dog’s diet and then slowly reintroduce foods one at a time after symptoms have resolved. So how do you determine what the possible allergens or intolerances are? Easy, any food ingredient your dog has been exposed to in the last couple of years is a potential allergen.

The most common dog allergies, in order, are beef, dairy, chicken, wheat, soy, lamb, corn, and eggs. But your dog can become allergic to any food they have previously been exposed to.

Look at the ingredients label on your dog’s food bag. Write down every whole food ingredient you see. While it is possible for a dog to be allergic to synthetic vitamins, preservatives, and other minor ingredients, it is less likely. Add to that list any foods your dog has gotten as a treat, licked up off the floor, and flavors included in their medications or supplements.

This is your list of foods your dogs cannot have for the next few months. Your challenge now is to find a dog food that does not contain ANY of these ingredients. I would recommend looking for a limited ingredient diet that contains only one protein and one starch. If your list includes multiple common proteins and veggies, you may have to hunt for a food with less common ingredients like venison and sweet potato or rabbit and oatmeal.

Slowly switch your dog from their original food to the new food over the course of a few days. Once they are completely on the new food, restrict your dog’s diet (treats included) to only items NOT listed on the potential allergens list you created.

You will need to continue this restricted diet until your dog’s symptoms clear. For skin allergies, that often means waiting two to three months. If your dog’s symptoms don’t improve in this time, try a diet with different ingredients. If there is still no improvement, it is unlikely you are dealing with a food allergy or sensitivity.

Once symptoms have cleared, then you can choose one food from the restricted list to add back in. Feed only this modified diet for at least a month or two. If symptoms return, you know your dog is allergic to that reintroduced food. Remove the food from their diet completely, wait for symptoms to resolve, then try another food from the list. Ideally, after multiple trials, you will be able to find a complete and balanced diet with multiple proteins and starches that your dog can eat without showing any symptoms of allergic dermatitis.

Even if your dog doesn’t suffer from allergies or intolerances, food may be to blame. Poor quality diets can lead to a dry, brittle coat, and itchy skin. If your dog is on a less than optimal diet, try changing their food to one that contains multiple quality named animal ingredients at the beginning of the list, no filler ingredients like corn or soy, and no synthetic dyes or preservatives. Look for a food that has at least 25% protein and is high in healthy fats as well.

Often, this change alone can make a huge difference in the health of your dog’s skin and coat.

3. Ruling Out Infections and Parasites

The first step in your dog’s itchy skin journey probably included a battery of tests to rule out parasites like fleas, mites, and other skin infections. (If it didn’t, this is definitely something you should do now.) But often, these tests miss common causes of dermatitis.

Flea allergies are most common in dogs who only rarely have fleas, and it only takes one bite to set off a week’s worth of itching misery. This minor or intermittent degree of infestation can be easily missed in the vet’s office and should not be ruled out just because flea dirt isn’t visible.

Even mange can be misdiagnosed. Some mites live so deep within the dermal layer that they aren’t readily detected through normal skin scrapings and may take repeat tests to diagnose. If your dog has other symptoms of mange, but your original test was negative, you may want to talk to your vet about additional tests.

Some dogs, especially those with thyroid problems and other environmental allergies, can even be allergic to the staph bacteria. This microbial is present on most surfaces, including a healthy animal’s skin.

This and many other infections that cause allergic reactions can only be determined through blood tests that detect antibodies. This may be a worthwhile step to pursue for your dog if there is a possibility their allergic dermatitis is caused by an environmental or contact allergen or infection.

Sometimes vets will put a dog on a course of antibiotics to rule out bacterial-induced dermatitis. While this can be a helpful diagnostic tool, keep in mind that some infections take multiple rounds of antibiotics to knock out and that yeast infections, often made worse by antibiotics, can also cause itchy skin.

The most important thing to remember here is to work with your vet and exhaust your options before ruling out an infection, parasitic or otherwise, as a cause of your dog’s itchy skin. You may even consider taking your dog to a specialized veterinary dermatologist.

4. Supplements 

Just as switching your dog to a higher quality food can help fight itchy skin, so can some supplements.

Fish oil is one of the first supplements that comes up when talking about itchy skin. That’s because this oil is full of omega fatty acids. Omegas are key to your dog’s skin and overall health and can be especially effective in relieving itch. In fact, about 20% of dogs with dermatitis show reduced itching with the use of an omega supplement alone. Since these fatty acids are a healthy addition to any dog’s routine, there really is no downside to giving them a shot.

Digestive enzyme and probiotic blends made specifically for dogs can also be helpful in relieving the itch, especially if your dog suffers from an unknown food sensitivity or intolerance.

Enzymes help break down specific foods in your dog’s stomach. If your dog lacks a certain enzyme or does not produce enough on their own, that food can move through the system undigested and cause unnecessary immune response or nutrition deficits that in turn cause itchy skin.

Similarly, probiotic organisms help break down particles in the gut that your dog is unable to digest themselves. Healthy intestinal flora is key in helping your dog absorb needed nutrients, including many that are important for skin and coat health.

Yucca and quercetin are also great natural alternatives to Apoquel. Yucca has an effect similar to steroid drugs without the harmful side effects. Quercetin is a plant derivative that acts as a natural antihistamine and is a great option for dogs whose itching is reduced by Benadryl.

5. Topical Remedies

There are a number of topical balms and ointments marketed to dogs with itchy skin. Many owners find these products useful, especially for flare-ups and treatments for hot spots.

But you don’t have to spend a fortune on pre-made remedies to find relief for your pup’s itchy skin. Many common items, maybe even some in your pantry right now, can be used to tame your dog’s itchy skin.

Coconut oil is a natural skin soother with antibacterial and healing properties. It can be applied directly to the skin as is or mixed with a little lavender or peppermint essential oil for a truly relieving skin treatment.

Green tea, chamomile tea, baking soda, oatmeal, and apple cider vinegar are all natural anti-inflammatory products that can be mixed with water for a therapeutic soak. While it may take some work to get your dog to stay still long enough to reap the benefits, they’ll likely thank you for that tough love once they feel the relief.

Cure the Cause, Not the Symptom

While supplements and topical remedies are excellent options for soothing your dog’s itchy skin, keep in mind that they will not cure the underlying cause.

If you ever want your dog to live a life free from painfully itchy skin, and free from costly and sometimes dangerous medications like Apoquel, you have to figure out why the symptom exists in the first place.

My training client, the boxer, spent the first couple years of his life battling itchy, inflamed skin. Then the next half-decade fighting the side-effects of Apoquel and other drugs. What he needed was not a miracle cure for his dermatitis, but a diagnosis for what was causing the symptoms in the first place.

Whether you choose to use Apoquel, another drug, or a natural remedy to deal with your dog’s itching while you search for the underlying illness or allergy, just make sure you never stop searching. Not until the itching is gone for good.


Sally B. Cosgrove, et al. “Long‐term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of lifewiley.com, 16 February 2015.

Various. “Apoqueldrugs.com.

Karen A. Moriello. “Itching (Pruritus) in Dogs” merckvetmanual.com.

Various. “Canine Allergic Dermatitis: Causes and Treatment Optionsanimalmedcenter.com.

Ralf S. Mueller, et al. “Critically appraised topic on adverse food reactions of companion animals (2): common food allergen sources in dogs and catsbmcvetres.biomedcentral.com, 12 January 2016.

Various. “Allergy Shots May Bring Relief to Itchy Dogsvetmed.illinois.edu, 27 November 2017.

Cynthia Foley. “Will Your Allergic Dog Benefit From a Food Elimination Diet?wholedogjournal.com, 12 February 2015, Updated: 21 March 2019

Various. “Natural Supplements for Dogs With Itchy Skin.” petmd.com.

Sara Seitz worked in the pet industry for over a decade. In addition to being a certified dog trainer, Sara gained experience working as the general manager of a dog daycare and boarding facility, as the creator and manager of a pet sitting company, as a groomer, and as a dog behavior evaluator. She also has a bachelors in animal behavior from CSU. Currently, Sara works as a freelance writer specializing in blog, article and content writing.  

70 thoughts on “5 Apoquel Alternatives That Are Better for Your Dog”

  1. Thank you so much for this information on not only alternatives to Apoquel, but for explaining the side effects. My vet only mentioned this medicine could cause problems with their white cell count but did not mention anything else. Apoquel did seem to be a miracle drug for my dog who is an Aussie/Hound (fox/coon/beagle) mix. She was a rescue and they only knew her mother was an Australian Shepherd but she looks more like a Fox hound and has very short hair with an undercoat. She sheds horribly half the year but she itches horribly all the time. Our vet said when the first frost comes her allergies should disappear (we live in Minnesota and have 30 degrees or less from November to Mid-April) but we are now at the end of December and the itching is the same. We tried Apoquel for one month and it worked like a miracle. But at a cost of $100.00 per month we prayed for winter to come quickly. When the cold weather came we stopped the Apoquel and the itching resumed. We have tried the steroids which did nothing but make her need to pee more, and she has put on weight, we have her on a very good simple ingredient dog food that comes from our pet store and highly recommended, we bathe her in a vet-created shampoo with lidocaine, we spray her with a witch hazel solution specifically for dogs, we soak her in water and baking soda, but even now she is outside dragging her belly and rubbing her nose is the snow to get some relief. It is so sad. She looks at me with “why am I so miserable ?” eyes. I will try the fish oil and coconut oil you recommended and will consider the immunotherapy to see if we can determine what the source of her misery is. We faithfully give her the flea and tick medicine that we get from our vet and it is far too cold for fleas and ticks where we live much of the year. Your article has at least given me the hope that there is something out there that can help. Even if I could afford Apoquel I am not willing to put her at risk for the side effects associated with it.

    1. Thank you for sharing your story with us and for reading our articles. We are glad we could help you with your troubles and commend you for trying to find better solutions for your dog’s health issues than just medications. All medications, including flea and tick, medicated shampoos, compromise your dog’s immune system and make her more succeptible to different health conditions in the long run. Raw food diet and bathing her using the most simple, natural shampoo/soap could probably be the most important changes you could make to help her feel better. Hope this helps and you find the right solution for both of you.

    2. We too have a rescue, Chihuahua mix that suffers from awful itching and we too live in Minnesota. We have had him four years and have been changing food, took Apoquel for about a year, now on cytopoint shots which last about 4 weeks before he needs another. Thank you for sharing and I’m going to try natural alternatives for relief

    3. Hi Melida what brand of food are you now giving your pup? My pup is miserable and between Apoquel and Cytopoint they no longer work. Now I realize why my dog’s white blood cells are always higher than normal. I’ve changed his food so many times. All these meds just make him gain a lot of weight.
      My dog will not take fish oil and coconut oil doesn’t help.

    4. I tried the fish oil and she took it for two days and she started with loose bowels. She weighs 15 lbs. How much should I give her

  2. I am looking for a less expensive alternative to apoquel can you help me Thank You in advance I need it too work also

    1. Thank you for your comment. Did you give a try to any of the suggested alternatives in the article? Perhaps #1 thing to try would be changing the diet, because most of the health issues come from within and food can be the major contributor to either health or sickness. Best of luck!

      1. For anyone whose dog is taking apoquel if you can get your Vet to give you a prescription you can purchase it at
        Walmart. If that doesn’t work you can also get it from Canada at half the price you were probably paying.
        Hope this is helpful for all of us on fixed incomes.

        1. I make my own dog food because of the itching. I,too, did not know the side effects of apoquel. It was working for a while but I’m not convinced it is a miracle drug. I am still using it. Just started about two weeks ago. The itching was driving me crazy and the dog had to be miserable. Will keep on trying to find the solution.

    2. I purchase 16mg Apoquel from Chewy.com I get 31 for the month and it’s under $70.00, free shipping for $49.00 and over.

  3. Thank you very much my dog was on a lot of medications and I really didn’t know what to do and the vet offered to give him the apoquel but didn’t tell me about the side effects. I was already a little nervous about him taking it however with your article I feel much better on finding alternate sources.

      1. I was thinking along those lines as well. My Rosy is very fussy but she finally decided she liked the expensive raw freeze dried True Dog brand. I bought it because she’s so itchy and has been on Apoquel multiple times. I am seeing the mangey side effects on her ears so I’m not happy. I’m going to try coconut oil supplement topically and apple cider vinegar in her water but not so much that she won’t drink her water..
        Wish us luck.

        Stacie and Rosy

        1. I tried the apple cider in the water and my gsd stopped drinking water unless shes dying of thirst…..I’m thinking of trying the acv pills they have now….

  4. Our dog has seasonal itching/allergies. Our vet thinks it’s because of our wood stove and the dry heat. He suggested Apoquel for the winter months. I didn’t realize she could be dependent on it. Thank you

  5. I’m trying to keep my terrier mix off Apoquel. Chronic use becomes expensive and when I looked further into it, it lists mange as a side effect. Now that seems really counter intuitive.
    I changed her diet to TruDog freeze dried raw turkey or beef. That has helped her a little. She’s a very fussy eater. She has grown to like this high quality not inexpensive food.
    I also supplement her with probiotics , omega 3 fatty acids, CoQ10 and other good stuff in a chew. She thinks it’s a treat. I also rub pure coconut oil on her itchy spots topically.
    She’s feeling more comfortable without the pill.

  6. So, do you stop the Apoquel cold turkey or must they be weaned off of it, if we were to try a new diet and yucca supplement? My 13.5 yr old GSD had a very serious skin infection in Sept 2019 and it has since cleared w diet change and Apoquel. I tried stopping Apoquel and using skin/allergy supplements but the itchy red skin came back quick. I’m now using a Salmon kibble, Missing Link supplement for skin, and Apoquel.

  7. Outstanding article and really appreciate the information on alternatives for what was the first dog drug (Apoquel for 2 weeks) we have used for our Itchy girl who has been suffering for many years. Sadie we believe is alergic to dust mites as this is not seasonal and has only hot spots on her feet. She does have chronic ear issues. We believe her diet is fine and no signs after eating or in stools of any issues. her coat seems to be fine as well. I am going to try the Quercetine and Yucca and bump the Fish oil up abit.

    Thanks again- Bob

  8. My cockatoo has itchy ears & before apoquel inflamed .Its very pricey & I was not aware of the side effects , can you suggest an alternative that would help her ears .

  9. Thank you soooooo much for getting this information out there to inform people like me about the horrible risk of giving your dog (or cat) this drug. I’ve always followed my vet’s instructions without question until I started doing research of my own after my dog died of cancer at 6 y/o. Your information and the few others that are successful in getting their messages out saved my cat so much suffering. After being on Apoquel for a couple months I read about it’s horror’s. Started on elimination diet and eventual LID. She is wonderful today with just the occasional irritation every month or so that passes within a day or so and is much less extreme. I suspect it’s after she found a treat on the floor! Such a relief to know that her immune system is not being harmed and she is feeling better.
    You have given my cat, Bean, a better life. I will spread the word! Keep it up and thank you so very much for your work.

  10. karen schindler

    From Karen @ [email protected], Read your review I want to discontinue my 6 lb chihuahua off apoquel. and replace with omega supplements and the coconut oil. how did you stop the apoquel. I have put him back on grain free food , please feel free to e-mail me .thank you!

  11. karen schindler

    After reading all the side effects and the rising price of Apoquel. Is it safe to discontinue it and use salmon omega supplements? Changed diet to Grain free salmon,sweet potato, and pea kibble. My chihuahua weighs 6 lbs


  13. Any suggestions for my 7 yr old rescue dog…very itchy skin, and now warts..3rd one. On a good diet now but still itchy and worried about warts. Thanks

  14. My 9 year old shiz tzu has been on Apolquel for several years. She was allergy tested and found to have a great many food allergies. Therefore I make her food, which consists of vegetables she is not allergic to and about a tablespoon of meat, such as salmon, which are not on her allergic list, and a special kibble. She gets Salmon oil and coconut oil in her food as well. I checked out Raw food and found all of it had combinations that included items she cannot have. Since she continued to itch on this diet it was believed she also had environmental allergies and was put on the apoquel, which has greatly helped the itching.

    Recently she was diagnosed with “early dementia”. After learning that some allergy meds can cause dementia I am concerned that this was caused by the apoquel. I wonder if anyone else has experienced this. I decreased the apoquel to every other day without a return of itch symptoms. I am wondering about discontinuing it altogether.

    1. My pug is sometimes itchy. For the past 3 or so years she has been losing her hair symmetrical alopecia. I have talked to vet a few times about it. Was recommended Apoquel. Tried for a couple months. Too expensive. Tried making her food. Some improvement skin went from black to pink but still slow continual hair loss under belly and legs and thinner over all coat that doesn’t grow back. She gets cold easily now. I have tried bathing her a bit more now too to help rule out possible environmental allergies. Frustrated.

      1. Has your pug been tested for hypothyroidism? Hair loss and cold intolerance can be signs. How about constipation? Overall lethargy or weight gain?

  15. I’ve learned a great deal from the commentary and appreciate the robust discussion on controlling pet allergies, thank you. My pet (terrier mix) is a rescue dog, We’re not sure of her age but estimate she’s around seven years old. . She has been on Apoquel for a long time, I’m weaning her off the Apoquel and giving her Zyrtec during and benedryl at night. I’ve also switched to Farmer’s Dog food which I believe is helping. We bath her with Johnson’s No More Tears baby shampoo, I brush her a couple of times a day and give her an ear wash (a mixture of boric acid powder, Genetian Violet drops and Isopropyl alcohol) when she starts scratching. There is definite improvement, Farmers Dog has been very responsive in working with me on her diet, her coat looks much better and her eyes are clear. I’m going to introduce fish oil into her diet and will continue to monitor her progress. The zrytec works much faster and seems to last throughout the morning and afternoon. She’s more engaged and alert and not sleeping as much during the day. Finding what works for your dog is a process, it’s trial and error. I hope some of my ideas might be of benefit.

    1. Thank you Gretchen your comments were very timely for me and my 2 year old GSD!!. Also, thanking the people who started this site. The suggestions and comments from all are so helpful!!
      I have just ordered Dr. Dodd’s food test for Ina. It is expensive but came highly recommended by my wholistic vet. I did not know the extent of issues with apoquel. She has been on it for a year. The Dr. Dodd’s test center recommended Zrytec through the 2 week process while removing her from apoquel. in order to successfully take their food test; the wholistic Vet gave me an Okay to do it. I’m coming back to this site on a regular basis several options. are noted that I have not yet tried I will be discussing them with this vet -also I send notes to my regular vet. Ina (my GSD) also has had the mange connection with the test coming back positive for sarcoptic mange ( humans and sometimes other pets can contract this- I did not and neither did my cat now I wonder if the dog really had it?). The wholistic Vet just explained to me that the mange test can show up positive when dust mites are known as sensitive to the dog. She has been treated previously with Revolution for heartworm also used for mange treatment. I can’t wait to get her off everything! Thank you to everyone who contributed now and in the future to this site. I feel optimistic that we may finally be on the way to figuring this out! I also feed raw and cook the remainder of her food. I use no kibble as she tested high for storage mites as well. Thanks to all!

  16. I have two golden retrievers that have been experiencing itching and hotspots. The vet put them on Apoquel. The very first thing I noticed was them becoming lethargic. So I cut them in half. But the itching hasn’t stopped. It’s probably fair to say that I did not give that drug a good chance but after reading your article I have decided I don’t want anything to do with that medicine. I know that living in Florida there are lots of allergens most of the time. I do think we have more weeds since hurricane Michael went through. So I still feel the source of the itching is from the weeds that I am fighting. I have been treating the yard for fleas and spraying the weeds to get this under control. I will start them on Fish oil. It does seem to get better in the winter. But we have summer down here at least eight months out of the year. I will definitely try some of the remedies that you have mentioned in your article. Thank you so much for this information and I am optimistically looking forward to good results.

  17. Marcia Jennings

    I put my dogs on Apoquel this year. I am 70 on fixed income but they come first! I got a part time job. It ishelping my 92 lb Bernese mix but has stopped on my pug/shitsu mix. I give them very good food, no fleas in the yard, Change my filters monthly. Gave baths with oatmeal shampoo. I am concerned about cancer in my Benderse!
    I don’t know what else to do for them but want them off the Apoquel. It kills me to see them suffer! Is it safe to take them off cold turkey?
    Thank you!!!

  18. I came to this article hoping to find some alternatives to Apoquel, like the title suggested. Instead I find a list of things we’ve already done years ago. The vets have all assured me we will never find the cause of my dogs allergies. He’s already been on prednisone, which worked the best, then we tried cytopoint; which did absolutely nothing, and now Apoquel, which helps some but not really. I guess it’s back to prednisone if the vet will give it to him again. He was taken off it because of side effects that could happen with long term use. But I can’t afford Apoquel anymore, and it doesn’t help much at all anyway. To me the dogs quality of life is at stake.

  19. My mini dachshund has been battling food intolerances for 6 years. With the help of a dermatologist vet we tried the elimination diet, it worked, but people giving table ‘treats’ and trying to reintroduce previous proteins to see what was triggering her has been a total disaster. If you are lucky enough to find a novel protein which doesn’t give an allergic reaction please DO NOT try your dog on ANYTHING else they have previously eaten because that’s how we have now run out of novel proteins to try. Also, you state to introduce the new diet slowly into the existing food but in our experience, that is also a resounding no. When I have a novel protein, she could have none of her previous food with it because her body would then trigger with the new protein. This is why I said do not reintroduce foods. Seriously, after 6 years of battling this, I wish I’d cared less about narrowing down what it was that set her off because she is now triggered by everything on the market, even specialist hypoallergenic foods. And what does it matter if you don’t know exactly if the new food doesn’t trigger a reaction? The only novel protein I haven’t tried is crocodile and that’s because I can’t get it here in the UK but I have been through all other proteins with her raw diet (the usual domestic farm animals but also ox, kangaroo, ostrich, wood pigeon, quail, literally everything available through raw dog meat suppliers).
    Do you have a recommendation of where to buy the yucca and quercetin please?
    Thank you.

  20. Thank you so much for the article just reading it we have good ideas to find the cause of our dogs allergies thank you so much and also good ideas of how to treat the symptoms without apoquel thank you so much

  21. Our 5 year old pet Bullador has itchiness and allergies throughout the year. Thats how it started at 5-6 months of age. Gradually increasing. He would often get given antibiotics for the infection and sterods. He was on majority raw diet and some kibble. After doing the food elimination we suspected it was the chicken or lamb causing it. Switched to Vet diet. WHile it seemed to help However the itchiness would be there though not as bad as before. Finally he is now on CYTOPOINT the last 1 year . It lasts for 6-7 weeks but then he needs to have that shot again. No sideeffects yet. We suspect it is a combination of food and allergens causing his issues or it could just be that his skin barrier is weak (Atopy) and may never be treatable. However we have been advised that resistance may develop towards Cytopoint.

  22. Appreciate the information on Aoquel for 1 1/2 because of scooting/anal glands. Using 8mg once a day which seems to help. She is a 10/11 year old red heeler (supposedly) we adopted 2 years ago and know nothing about her past. Am concerned about these side effects especially since she has put on a lot of weight since her adoption. She is not an active dog but follows me around everywhere so if I’m moving around a lot, then she is also. Noticed all the posts are for allergies and itchy skin. Suggestions for the scooping situation. Her groomer and vet both express her glands on visits. Have read pros and cons pm this also.

    1. In June my gsd put her head in a wasp nest and got stung several times on the face. Since then her face has been really itchy and the skin is thickened. She had apoquel for several weeks which totally fixed the problem with no visible side effects. I wasn’t happy with giving it to her so I stopped and the itching has returned. Any suggestions? So I know the cause but don’t know what to do.

  23. I have a now 10 year old Field Lab who has suffered from extreme itchy for years. I too put him on Apoquel a few years ago and found that it indeed stopped the issue. It however is very expensive and as it turns out at least in my case seems to introduce cancerous lesions. I’ve had many dogs over the years including Labs. This guy is the only one so itchy and the only one I’ve used this drug on. About a year into Apoquel we found a 50 cent piece size soft red bump on his side. LIke many Labs he also has had fatty cysts of the same size as he got older. None of these ever concerned a Vet. This red one with no hair on it did. After a couple opinions we had it removed with surgery. This was a massive wound with about 8 inches of stitches that took us 3 months to heal. I’ve had him off Apoquel for about a year. He’s itchy as ever but no more lesions. I use medicated shampoo’s on him and feed him good food. I’m kind of at the end of my rope and he’s quickly aging so I don’t expect to make many more changes but still hold out hope for some relief that isn’t a pharmaceutical.

  24. I read on Google that a new chew works as well as Apoquel, it’s called PETLAB.CO , do you believe this to be true? It is also 1/2 the price and a vet is not needed. Looks like the ingredients are safe and natural also. Please, let me know what you think so l can replace the Apoquel. My dog had tests done and he is fine except his electrolyte s ( sp)? .My vet said he needs to drink more water, which is true. Thank you so much, please answer back! Betty Jo A.

    1. It’s hard to say with these products. Advertisements look amazing, but until you try you won’t know. There are quite a few problematic ingredients in that product, including wheat, corn, GMO soy – none of them are good for dogs in any shape or form. The best medcine is real whole food and that is raw food for dogs.

      1. I am so glad I found this page I am actually making my self depressed with worry due to my Miniture Schnauzer Eddie’s itching problem. I took him to the vet and they prescribed apoquel and it worked almost instantly. I then decided to do a bit of research regarding the the drug online and was horrified so I took him off it immediately!! I am very passionate about making sure my two dogs only eat products that do not have wheat and grains in. They are currently on Forthglade wet food with no kibbles which is very high meat content (Im hoping its not the food). I am replying because the previous post mentioned Petlab.co. chews. Eddie has been taking them diligently for over a month now and there has been no change at all. There are many good reviews regarding their products and I thought I would give it a go, this post is not intended to criticise Petlab.co.at all in fact I contacted them only yesterday to inform them that the product had not made any difference to my dog and to be fair they have offered to give me a full refund for the chews. I can’t fault how quickly and professionally they have been. I think it was just a case of you win some you lose some and in Eddies case they just didn’t work. My question to Ultimate Dog is, what are your feelings regarding Homeopathy? There is a product called Ditch the Itch which are homeopathic tablets. I am so desperate to find a solution for Eddie he is so down and depressed looking. This morning I awoke to find he had itched his tail so much it was bald and red raw. I appreciate that the key to the cure is to eliminate the cause but how long does he need to go on suffering to find the solution? Im so thankful that you have given me a few more options to try.

        1. Hi Christine,
          Thank you for your comment. I believe homeopathy could be a lifesaver, but I would suggest working with a local homeopathic vet, if possible, and finding the correct remedy for Eddie specifically. Homeopathy is highly individualized medicine and very often one size does not fit all, as is often the case with many commercial homeopathic products, which makes people think that homeopathy does not work.
          To find a vet go here: https://theavh.org

  25. My Cockerpoo has been on Apoquel for more than a year and it worries me. Can I give fish oils and coconut oil together or has it got to be one or the other. He is about 12k.
    Thank you.

  26. Just started my 10 year-old terrier on this med before reading all of this and am very concerned. I have him on a prescription food from our vet for his stomach and has done better but I know he has allergies and have tried many things. He has one dosage of Apoquel in him and he has not been biting at his feet. This year has been worse than ever. Just concerned I am not doing the right thing for him. He came from a bad and unhealthy environment and I have had him as a pup. Thank you for any information you might be able to add Thank you Kathy,

    1. I would not do any special prescription food. There is no such thing as prescription food. Have you tried real raw food? That’s what dogs are designed to eat and most of the time it solves all their health issues.

  27. Thank you for the info. As others have commented, we’ve tried all the alternatives already before we put Simba our 70kg (150lb?) Boerboel onto Apoquel. It was a big improvement on the steroid he’d been on for too long. Unfortunately we haven’t been able to reduce the initial loading dose of 4 tabs (the highest dose) for more than a few days. The cost has become ridiculous. Are there any generics coming out of India yet? That country has been a godsend regarding high priced cancer drugs, so I hope they help pet owners too!

  28. My dog is very allergic to flea saliva! What is the best Remedy to help with this? He has been bitten by what I found 4 fleas and has been off the wall itching and scratching for a month now with no end In sight. I give him children’s liquid Benadryl but it doesn’t seem to help. He’s not sleeping nor eating and neither are we. Help!!

  29. Kirsten Zielinski

    i was one of the first people whose dog was on apoquel. it was/is a miracle drug for a dog that had spent 6 or 8 years digging holes in himself due to allergies. otc does NOT work, at all. you can wash allergens off all you want, useless. realistically, you will need to chose between having a dog with little to no quality in life, to having one that does and may suffer side effects. my dog had no issues with it and when he was forced off of it because they could not get enough made due to how well it worked, his allergies were no worse than when he went on the drug. maybe they seem worse because you forget how awful they were. i never did. my dog never experienced any loss of energy or anything like that. i have never heard that from any of the people i know whose dogs have been on it. i suggest before you let your dog continue suffering from scratching themselves raw, you get poison ivy all over you body and do not treat it at all and then imagine living with that every day.

  30. I see no DVM by her name so take ALL of this information with a grain of salt. If you want to rule out allergies take your pet to a DERMATOLOGIST. This is the next best option if you’re absolutely unsure of using apoquel( I personally love the med and have seen pets in it long term at most effective dosing – give less over a period of time). Stop googling please cause then you come across pages like this telling you not to put your money in “ this” but here’s MY product you can by instead with absolutely no evidence. If it was that easy, veterinarians and veterinary schools would be out of business.

    1. Hi Jane,
      I believe people are ‘googling’ for information because they do not want yet another prescription from a DVM. Giving drugs to dogs is the easy part, finding real solutions to their health problems is not easy. We share honest and well researched information on prescription drug effects and do our absolute best to share evidence-based information on how to help our dogs heal without medication.

  31. You post this as 5 alternatives to Aboquel and all I mostly saw was an article that trashed Aboquel. Next time I think it would be better to title your article better. It is irritating when you think you are going to read one thing and get hit with another.

    1. Hi Tina,
      We do offer 5 alternatives to Apoquel in this article. The alternatives are not other drugs, but actual suggestions that could be used to get to the root cause of the allergies, so that we no longer have to drug our dogs. I do not believe the article title is misleading.

  32. Katy Morales🌺🌴

    My dog was prescribed for 2nd time with Apoquel, yes is expensive, but the side effects, I don’t want this for my doggy at all. What do you recommend for a Doxie, he’s 9yrs 16pounds 😩 about quercetin, yucca or other?? Please i have to help him🙏🏼❤️

    1. Please consider changing his food, as all conditions come from the gut health and if that is not in order, drugs will only make it worse. Supplements will help, but will not resolve the issue.

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